kemal
6bea6c4930
scripts/cloud/trial.sh launches one spot instance that validates the parsers on the 1000 Genomes Omni2.5 set (2141 samples, vendor GTCs) streamed from the public S3 bucket, uploads the summary and terminates itself. Cost guards: spot price cap, hard time limit (shutdown = terminate), EXIT-trap shutdown, CloudWatch idle alarm that terminates from outside, disk deleted with the instance, monthly budget alert, and an `audit` command listing anything still billable. scripts/validate_p1_large.py compares every GTC with BeadArrayFiles, checks byte-identical round-trips, IDAT pairs and BPM/EGT/CSV.
SimurgArray
Personal research toolkit for Illumina Infinium genotyping BeadChip data (IDAT → normalization → genotype calling → BAF/LRR → QC → VCF/PLINK; later CN/LOH, PGx, cluster training).
- SIMURGARRAY_MASTER_PLAN.md — architecture, algorithms, roadmap
- SIMURGARRAY_FUNCTIONAL_SPEC.md — 416 itemised requirements (CLI, inputs, outputs, QC, CN, PGx, methylation, edge cases)
docs/validation/— per-phase validation reports ·docs/known_unknowns.md— findings log ·docs/research/— background
Status
Phases P0 (setup) and P1 (file parsers) are complete — see docs/validation/P1.md.
Available commands: simurg version, simurg inspect <files…> [--json].
Quick start
uv venv && uv pip install -e ".[dev]"
uv run pytest tests/unit # no downloads needed
bash scripts/bootstrap_refs.sh # reference open-source repos → refs/ (oracles)
bash scripts/fetch_data.sh p0 # ~1.4 GB of public test data → data/
bash scripts/make_oracle_gtcs.sh # builds gtc2vcf, writes oracle GTCs
uv run pytest tests/oracle # real-data acceptance tests (add -m "not slow" to skip the long ones)
uv run simurg inspect data/p0/gsa_v4_pgx/idats_Demo_36/idats_Demo_36/207895980019/207895980019_R03C01_Grn.idat
Vendor data files are downloaded for personal research use only and are never committed. See THIRD_PARTY_NOTICES.md.