PGx phenotypes: pgx phenotype|annotate (PGX-024..028, CLI-034)

CPIC lookups by allele function counts or activity values (duplications N x activity, *5/*0 = 0, total-score
fallback), Indeterminate when feasible solutions disagree or an allele is not in the guideline; per-sample
simurg.pgx/1 JSON and diplotype_annotations.tsv with PGX-026 metadata lines.

src/simurg/core/errors.py

@@ -174,6 +174,7 @@ CATALOGUE: dict[str, MessageDef] = dict(
         _m("E_PGX_CN_MISSING", "error", "A sample has no PGx CN VCF (give --no-cn to run without)", "PGX-011"),
         _m("E_PGX_VCF_UNINDEXED", "error", "SNV VCFs for PGx must be bgzipped and indexed", "PGX-011"),
         _m("E_PGX_VCF_UNSUITABLE", "error", "SNV VCF unsuitable for PGx (squashing/locus filters/foreign)", "PGX-011"),
+        _m("E_PGX_GUIDELINE", "error", "Guideline tables not present in the PGx DB", "PGX-025"),
         _m("E_PGX_SOURCE", "error", "PGx source tables missing; run scripts/pgx/fetch_sources.sh", "PGX-001"),
         # --- methylation control QC (MET-001 .. MET-018) -------------------------------------------------
         _m("E_METH_NO_ASSAY", "error", "Probe section not found", "MET-002"),