CN: per-probe LRR noise from the batch reference (CYTO-042), --probe-lrr-sd/--no-probe-lrr-sd
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@@ -2447,6 +2447,11 @@ about **algorithms or numerics**, the plan wins. Each such conflict found during
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(CYTO-020) to a constitutional DEL with `HIGHFRACTION`. This catches constitutional deletions whose LRR is
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compressed towards the mosaic states.
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- **CYTO-042** `§10.2 · v2` **Per-probe LRR noise [OURS].** A model built with `--reference-gtcs` stores each
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probe's robust LRR SD across the reference (1.4826·MAD after removing each sample's median and the probe's
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reference median). `cn call` scales the sample's LRR emission SD per probe by that spread relative to the autosomal
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median spread, clipped to [0.5, 3]. Without the column, or with `--no-probe-lrr-sd`, every probe uses the sample SD.
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---
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## 7. Targeted PGx copy number (v2)
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@@ -3723,6 +3728,7 @@ Generated from the item tags (`build.py`). Phases: P0–P10 as in plan §18; `v2
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| CYTO-039 | Batch scale | §10, §19 | v2 | D-9, E-35 |
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| CYTO-040 | Degenerate samples | §10 | v2 | E-35 |
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| CYTO-041 | MF refinements | §10.3 | v2 | K-027 |
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| CYTO-042 | Per-probe LRR noise | §10.2 | v2 | K-027 |
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| PCN-001 | Region catalogue | §11 | v2 | B-23, C-G25, D-10 |
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| PCN-002 | Genotype every region [EMU] | §11 | v2 | B-23 |
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| PCN-003 | Inputs | §11 | v2 | A-G37 |
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