PGx: CYP2D6 structures from sub-region CN — *68+*4, *36+*10, *13 (PGX-013/018)

Sub-region CNs (p5, intron 2, exon 9) resolve full copies and *36/*68/*13 units; candidates carry the
tandem names, background alleles, and CPIC activity sums. GeT-RM: CYP2D6 13/15 top (NA12878 *3/*68+*4 and
NA11832 *1/*68+*4 exact), 15/15 within feasible; all genes 132/144.

tests/unit/test_pgx_star.py

@@ -97,3 +97,18 @@ def test_variant_based_gene() -> None:  # PGX-021: per-variant notation, diploty
     recs = {("1", 100): [{"id": "p1", "ref": "C", "alts": ["T"], "gt": "0/0", "gs": "0.5", "baf": "0"}]}
     gj, *_ = call_variant_gene("s", "s", m, recs, set(), StarOptions([], Path("x"), Path("y")))
     assert gj is not None and gj["genotype"] == "Reference" and gj["feasible_solutions"] == ["Reference/Reference"]
+
+
+def test_cyp2d6_structures() -> None:  # PGX-013 CN rules
+    from simurg.pgx.star import Cyp2d6Structure, cyp2d6_structure, structure_candidates
+
+    assert cyp2d6_structure(3, 2, 2) == Cyp2d6Structure(2, 0, 1, 0)  # *68 unit (NA12878 *3/*68+*4)
+    assert cyp2d6_structure(3, 3, 2) == Cyp2d6Structure(2, 1, 0, 0)  # *36 unit
+    assert cyp2d6_structure(1, 2, 2) == Cyp2d6Structure(1, 0, 0, 1)  # *13 hybrid
+    assert cyp2d6_structure(2, 2, 2) == Cyp2d6Structure(2, 0, 0, 0)
+    m = _model()
+    m.haplotypes = ["*1", "*4", "*10", "*2", "*5"]
+    names = {n for _, n in structure_candidates(m, Cyp2d6Structure(2, 0, 1, 0))}
+    assert ("*1", "*68+*4") in names and ("*68+*1", "*2") in names
+    names = {n for _, n in structure_candidates(m, Cyp2d6Structure(2, 1, 0, 0))}
+    assert ("*36+*10", "*4") in names and all("*36+*10" in n for n in names)