PGx: all CPIC gene kinds — G6PD, variant-based, HLA tags, *0 CN genes (PGX-006/007/021)

- DB build resolves the PGX-007 tag variants from the manifest's probes; coverage over all gene kinds.
- Variant-based genes reported per variant (rs.. REF/ALT | Reference) with the CPIC lowest-activity diplotype;
  tagging genes as positive/negative with the population caveat; GSTM1/GSTT1/UGT2B17 *0 from targeted CN.
- Case-insensitive phenotype keys (MT-RNR1). GeT-RM check extended to VKORC1 and the CN genes:
  131/144 gene calls (docs/validation/V2_pgx_star.md).

src/simurg/pgx/star.py

@@ -40,6 +40,9 @@ class GeneModel:
     freq: F64  # (H,) population frequency of each haplotype (prior)
     deletion_allele: str | None = None  # named whole-gene deletion (CYP2D6 *5), or "*0"
     reference: str = ""
+    basis: str = "star_allele"  # PGX-002 result basis: star_allele | haplotype_named | variant_based | tagging_variant
+    activity: dict[str, float] = field(default_factory=dict)  # allele → activity value (variant-based ordering)
+    function: dict[str, str] = field(default_factory=dict)
 
 
 @dataclass