/* Palette: pale slate paper, ink navy, and one plum accent reserved for pathogenicity. */
:root {
  --paper: #f3f5f7;
  --ink: #16243a;
  --ink-soft: #52627a;
  --line: #cfd6df;
  --plum: #7a1f5c;
  --plum-soft: #f0dbe8;
  --amber: #b86a00;
  --mono: 'JetBrains Mono', ui-monospace, monospace;
  --sans: 'Source Sans 3', system-ui, sans-serif;
}
html { background: var(--paper); color: var(--ink); font-family: var(--sans); font-size: 17px; }
body { margin: 0; }
main { max-width: 1280px; margin: 0 auto; padding: 2.5rem 1.5rem; }
h1 { font-weight: 600; font-size: 2rem; letter-spacing: -0.01em; margin: 0 0 0.5rem; }
h2 { font-weight: 600; font-size: 1.25rem; margin: 2rem 0 0.75rem; }
p.lede { color: var(--ink-soft); max-width: 60ch; margin: 0 0 2rem; }
a { color: var(--plum); text-underline-offset: 3px; }
a:focus-visible, button:focus-visible, input:focus-visible, select:focus-visible { outline: 3px solid var(--plum); outline-offset: 2px; }
button { font: inherit; padding: 0.5rem 1rem; border: 1.5px solid var(--ink); background: var(--ink); color: white; border-radius: 4px; cursor: pointer; }
button.quiet { background: transparent; color: var(--ink); }
input, select { font: inherit; padding: 0.45rem 0.6rem; border: 1.5px solid var(--line); border-radius: 4px; background: white; }
table { width: 100%; border-collapse: collapse; background: white; border: 1px solid var(--line); }
th, td { text-align: left; padding: 0.55rem 0.75rem; border-bottom: 1px solid var(--line); vertical-align: top; }
th { font-weight: 600; color: var(--ink-soft); }
td.coord, td.hgvs { font-family: var(--mono); font-size: 0.85rem; }  /* aligned digits matter here */
.score { display: inline-block; min-width: 3.2rem; text-align: right; padding: 0.1rem 0.4rem; border-radius: 3px; font-variant-numeric: tabular-nums; }
.score.high { background: var(--plum); color: white; }
.score.mid { background: var(--plum-soft); color: var(--plum); }
.empty { padding: 2rem; border: 1.5px dashed var(--line); color: var(--ink-soft); }
.status { font-weight: 600; }
.status.failed { color: #9a1b1b; }
.status.running, .status.queued { color: var(--amber); }
.progress { display: flex; align-items: center; gap: 0.6rem; color: var(--ink-soft); margin: 0.25rem 0 1rem; }
.progress .hgvs { font-size: 0.85rem; }
.spinner { width: 0.9rem; height: 0.9rem; flex: none; border: 2px solid var(--line); border-top-color: var(--plum); border-radius: 50%; }
@media (prefers-reduced-motion: no-preference) {
  button { transition: background 120ms; }
  .spinner { animation: spin 0.9s linear infinite; }
}
@keyframes spin { to { transform: rotate(360deg); } }

/* --- triage ------------------------------------------------------------------------------- */
.muted { color: var(--ink-soft); }
.actions { display: flex; align-items: center; gap: 1rem; }
.reportlink { font-weight: 600; }
.provenance { font-size: 0.85rem; margin: 0.35rem 0 0; }
.casehead { margin-bottom: 1.25rem; }
.casehead h1 { margin-bottom: 0.4rem; }
.log { white-space: pre-wrap; background: white; border: 1px solid var(--line); padding: 0.75rem;
  max-height: 14rem; overflow: auto; font-size: 0.8rem; }

.chips { display: inline-flex; flex-wrap: wrap; gap: 0.35rem; align-items: center; }
.chip { font-size: 0.78rem; padding: 0.12rem 0.5rem; border-radius: 999px; border: 1px solid var(--line);
  background: white; color: var(--ink-soft); white-space: nowrap; }
.chip.match { background: var(--plum-soft); border-color: transparent; color: var(--plum); font-weight: 600; }
.chip.rare { border-color: var(--ink-soft); color: var(--ink); }
.chip.impact { background: var(--ink); border-color: var(--ink); color: white; }
.chip.model { border-style: dashed; color: var(--ink); }
.chip.clinvar { background: #fdf1df; border-color: transparent; color: var(--amber); font-weight: 600; }
.chipx { background: none; border: none; color: inherit; padding: 0 0 0 0.3rem; cursor: pointer; font: inherit; }

/* The funnel is the headline: thousands of variants down to a handful. */
.funnel { list-style: none; padding: 0; margin: 0 0 1.5rem; display: grid; gap: 0.35rem; }
.funnel li { display: grid; grid-template-columns: 4.5rem minmax(6rem, 14rem) minmax(0, 1fr);
  align-items: center; gap: 0.75rem; }
.funnel-value { font-family: var(--mono); font-size: 1.05rem; text-align: right; font-variant-numeric: tabular-nums; }
.funnel-label { color: var(--ink-soft); font-size: 0.9rem; }
.funnel-track { background: white; border: 1px solid var(--line); height: 0.75rem; border-radius: 2px; }
.funnel-bar { display: block; height: 100%; background: var(--plum); opacity: 0.75; }

.filters { display: flex; gap: 0.5rem; flex-wrap: wrap; align-items: center; margin-bottom: 1rem; }
.triage { display: grid; grid-template-columns: minmax(0, 1fr); gap: 1.25rem; align-items: start; }
@media (min-width: 62rem) { .triage { grid-template-columns: minmax(0, 1fr) 24rem; } }

.candidate { display: grid; grid-template-columns: 2rem minmax(10rem, 16rem) 1fr auto auto; gap: 0.75rem;
  align-items: center; width: 100%; text-align: left; background: white; color: var(--ink);
  border: 1px solid var(--line); border-left: 3px solid transparent; border-radius: 4px;
  padding: 0.6rem 0.75rem; margin-bottom: 0.4rem; font: inherit; cursor: pointer; }
.candidate:hover { border-left-color: var(--plum-soft); }
.candidate.selected { border-left-color: var(--plum); background: #fbf7fa; }
.candidate .rank { font-family: var(--mono); color: var(--ink-soft); }
.candidate .who { display: flex; flex-direction: column; gap: 0.1rem; }
.candidate .who .coord, .candidate .who .hgvs { font-size: 0.78rem; color: var(--ink-soft); }
.rankscore { display: flex; align-items: center; gap: 0.5rem; }
.scorebar { width: 4rem; height: 0.5rem; background: var(--line); border-radius: 2px; overflow: hidden; }
.scorebar span { display: block; height: 100%; background: var(--plum); }
.scorenum { font-family: var(--mono); font-size: 0.85rem; font-variant-numeric: tabular-nums; }
.decision { font-size: 0.72rem; text-transform: uppercase; letter-spacing: 0.04em; font-weight: 600; }
.decision.shortlisted { color: var(--plum); }
.decision.dismissed { color: var(--ink-soft); }

.panel { background: white; border: 1px solid var(--line); border-radius: 4px; padding: 1rem; position: sticky; top: 1rem; }
.panel-head { display: flex; justify-content: space-between; align-items: start; gap: 0.5rem; }
.panel h3 { margin: 0 0 0.5rem; font-size: 1.05rem; }
.panel h4 { margin: 1.1rem 0 0.4rem; font-size: 0.78rem; text-transform: uppercase;
  letter-spacing: 0.05em; color: var(--ink-soft); }
.panel input, .panel textarea { width: 100%; margin-bottom: 0.5rem; font-family: inherit; }
.components { border: none; background: none; }
.components th { font-weight: 400; color: var(--ink-soft); padding: 0.15rem 0.5rem 0.15rem 0; }
.components td { padding: 0.15rem 0; font-size: 0.82rem; text-align: right; }
/* A component with no evidence behind it is stated, not drawn as a number. */
.components tr.abstained th, .components tr.abstained td { color: var(--ink-soft); font-style: italic; }
.evidence { display: grid; grid-template-columns: 7rem 1fr; gap: 0.2rem 0.5rem; margin: 0; font-size: 0.88rem; }
.evidence dt { color: var(--ink-soft); }
.evidence dd { margin: 0; }
.links { display: flex; gap: 0.75rem; font-size: 0.85rem; }
.decide { display: flex; gap: 0.5rem; }

.newcase { display: grid; gap: 0.6rem; margin-bottom: 1.5rem; }
.newcase .row { display: flex; gap: 0.5rem; flex-wrap: wrap; }
.newcase button { justify-self: start; }
.picker { position: relative; display: grid; gap: 0.4rem; }
.picker .results { list-style: none; margin: 0; padding: 0.25rem; background: white;
  border: 1px solid var(--line); border-radius: 4px; max-height: 12rem; overflow: auto; }
.picker .results button { width: 100%; text-align: left; border: none; padding: 0.3rem 0.4rem; }
.picker .results button:hover { background: var(--plum-soft); }

.caselist { list-style: none; padding: 0; margin: 0; }
.caselist li { display: flex; flex-wrap: wrap; gap: 0.75rem; align-items: center; padding: 0.7rem 0.75rem;
  background: white; border: 1px solid var(--line); border-radius: 4px; margin-bottom: 0.4rem; }
.casename { font-weight: 600; min-width: 10rem; }

.report { background: white; border: 1px solid var(--line); padding: 2rem; }
.reportitem { border-top: 1px solid var(--line); padding-top: 0.75rem; margin-top: 0.75rem; }
.reportitem h3 { margin: 0 0 0.4rem; }
.dismissed { color: var(--ink-soft); }
.disclaimer { margin-top: 2rem; padding-top: 1rem; border-top: 1px solid var(--line);
  color: var(--ink-soft); font-size: 0.85rem; }
@media print { .noprint, nav { display: none; } .report { border: none; padding: 0; } }
.note { color: var(--ink-soft); font-size: 0.88rem; border-left: 3px solid var(--line);
  padding: 0.35rem 0 0.35rem 0.6rem; margin: 0.5rem 0 1rem; }