# Test data

No patient data. Use public sources only:

- ClinVar VCF (GRCh38): https://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh38/
- gnomAD exomes subset for allele frequencies
- A small HG002 (GIAB) chr22 slice for a realistic germline sample

```bash
# Example: 2,000 ClinVar variants on chr22 as a smoke-test VCF
wget -O clinvar.vcf.gz https://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh38/clinvar.vcf.gz
tabix -p vcf clinvar.vcf.gz
bcftools view -r 22 clinvar.vcf.gz | bcftools view -H | head -2000 > body.vcf
(bcftools view -h clinvar.vcf.gz; cat body.vcf) | bgzip > example.vcf.gz
tabix -p vcf example.vcf.gz
```