Initial release: rarelens platform skeleton (AGPL-3.0)

End-to-end variant interpretation platform for rare genetic disease research:
SvelteKit UI, FastAPI + PostgreSQL API, Nextflow/Ensembl VEP pipeline,
LightGBM pathogenicity scoring with MLflow, K8s/ArgoCD/GCP infrastructure.
Public test data only; no clinical claims.

api/app/main.py

@@ -0,0 +1,28 @@
+from contextlib import asynccontextmanager
+
+from fastapi import FastAPI
+from fastapi.middleware.cors import CORSMiddleware
+
+from app.routers import jobs, predictions, samples, variants
+
+
+@asynccontextmanager
+async def lifespan(app: FastAPI):
+    # Warm the model cache here once ml/ is wired in.
+    yield
+
+
+app = FastAPI(title="rarelens API", version="0.1.0", lifespan=lifespan)
+app.add_middleware(
+    CORSMiddleware, allow_origins=["*"], allow_methods=["*"], allow_headers=["*"]
+)
+
+app.include_router(samples.router, prefix="/samples", tags=["samples"])
+app.include_router(jobs.router, prefix="/jobs", tags=["jobs"])
+app.include_router(variants.router, prefix="/variants", tags=["variants"])
+app.include_router(predictions.router, prefix="/predictions", tags=["predictions"])
+
+
+@app.get("/health", tags=["ops"])
+async def health() -> dict[str, str]:
+    return {"status": "ok"}