fix: overhaul the platform skeleton, add a serverless deployment track

An end-to-end audit found the repo could not build, test or run as shipped. This
fixes every finding, then adds a Cloud Run track so the demo costs about £1/month
idle instead of ~£150.

CI (red on its first run)
- api: setuptools could not build the package (flat layout with app/ and alembic/)
- web: missing @types/node; `vitest run` exited 1 with no test files
- pipeline: the stub run needed a gitignored VCF, and no process had a stub block
- ruff pinned, mypy configured, DB tests on real Postgres (pgserver locally, service in CI)

ML serving (scores were meaningless)
- the registered model now carries its own feature engineering and returns predict_proba,
  so serving sends raw columns and cannot drift from training
- resolve by registry alias (stages are deprecated in MLflow 3) and record the real
  version; re-scoring upserts instead of failing on the unique constraint
- ClinVar labels parsed from VEP's lowercase terms

Pipeline
- exact ref/alt recovered from a CHROM_POS_REF_ALT VCF ID; loading is idempotent
- job status reaches running/failed/succeeded, so the UI stops polling dead jobs
- DATABASE_URL travels in the environment or a Nextflow secret, never on a command line
- VEP cache and plugins staged as inputs; the gcp profile runs tasks on Google Batch

Deployment
- the API serves /api (matching the ingress); the web app reads its API URL at runtime
- migrations run in an init container under a Postgres advisory lock
- terraform: custom VPC shared with Batch, private Cloud SQL, API enablement, Workload
  Identity bindings, Secret Manager, deletion protection
- serverless track, now the default: Cloud Run services scaling to zero, a Cloud Run job
  for the Nextflow driver, and Neon or Cloud SQL behind one DATABASE_URL secret. GKE and
  Argo remain, behind -var deploy_kubernetes=true. See docs/cloud.md.

Correctness and security
- 409 on duplicate sample names, 422 on bad paging, natural chromosome ordering, wider
  VEP text columns, enum dropped on downgrade, the sample's assembly actually used
- vcf_uri restricted to gs:// objects or files under the data root, blocking option injection
- CORS restricted to configured origins; `make down` no longer deletes volumes

Data
- docs/data.md records the peer-reviewed, openly licensed sources (GIAB HG002, ClinVar,
  gnomAD) with citations and an honest evaluation plan; `make data` fetches a chr22 slice

Verified: api 50 tests, ml 18, loader 16, web 12; ruff, mypy, svelte-check, terraform
validate and both kustomize overlays clean.
This commit is contained in:
Kemal Yaylali
2026-09-12 07:21:11 +01:00
parent 5463f489a3
commit 11fb6b3d73
100 changed files with 3431 additions and 340 deletions
+12 -1
View File
@@ -8,13 +8,24 @@ spec:
metadata: { labels: { app: api } }
spec:
serviceAccountName: rarelens-api
initContainers:
# alembic/env.py holds a Postgres advisory lock, so replicas starting together migrate once.
- name: migrate
image: rarelens/api
command: [alembic, upgrade, head]
envFrom: [{ secretRef: { name: api-secrets } }]
resources: { requests: { cpu: 100m, memory: 256Mi }, limits: { cpu: 500m, memory: 512Mi } }
containers:
- name: api
image: rarelens/api
ports: [{ containerPort: 8000 }]
envFrom: [{ secretRef: { name: api-secrets } }]
envFrom:
- secretRef: { name: api-secrets }
- configMapRef: { name: api-config }
readinessProbe: { httpGet: { path: /health, port: 8000 }, periodSeconds: 5 }
livenessProbe: { httpGet: { path: /health, port: 8000 }, periodSeconds: 10, failureThreshold: 6 }
resources: { requests: { cpu: 250m, memory: 512Mi }, limits: { cpu: "1", memory: 1Gi } }
securityContext: { allowPrivilegeEscalation: false }
---
apiVersion: v1
kind: Service