kemalandClaude Opus 5.5
662addf5eb
The mosaic BAF split is now estimated over heterozygous calls against each probe's expected noise (the reference heterozygous spread scaled to the sample), inverting the median of |N(+-d, sigma)|. A mosaic loss lacking the heterozygous calls its PFB predicts gets MF 1 and is promoted (CYTO-020). Co-Authored-By: Claude Opus 5.5 <[email protected]> Claude-Session: https://claude.ai/code/session_01814GKVzZVL3FuF3DeiZXhv