#!/usr/bin/env bash # Download SimurgArray datasets into data// and record sha256 checksums. # Vendor files are for personal research use only; never commit them. # Usage: bash scripts/fetch_data.sh p0|p1|p2 set -euo pipefail cd "$(dirname "$0")/.." tier="${1:?usage: fetch_data.sh p0|p1|p2}" mkdir -p "data/$tier" sums="data/CHECKSUMS.sha256"; touch "$sums" get() { # get local url="$1" dir="$2" f f="$dir/$(basename "${url%%\?*}")" if [[ -s "$f" ]]; then echo "have $f"; else if command -v aria2c >/dev/null; then aria2c -x8 -s8 -c -d "$dir" "$url" else wget -c -P "$dir" "$url"; fi fi grep -q " $f\$" "$sums" || sha256sum "$f" >> "$sums" } unpack() { # unzip/untar every archive under next to itself (idempotent) find "$1" -name '*.zip' -o -name '*.tar.gz' | sort | while read -r a; do out="${a%.zip}"; out="${out%.tar.gz}" [[ -d "$out" ]] && continue mkdir -p "$out" case "$a" in *.zip) unzip -q -o "$a" -d "$out";; *.tar.gz) tar -xzf "$a" -C "$out";; esac done } GDA=https://webdata.illumina.com/downloads/productfiles/global-diversity-array G1K=https://ftp.1000genomes.ebi.ac.uk/vol1/ftp/release/20130502/supporting/hd_genotype_chip case "$tier" in p0) # GSA v4 PGx demo: 36 samples, real IDATs + BPM/CSV/EGT (primary small fixture) SUP=https://support.illumina.com/content/dam/illumina-support/documents/documentation/chemistry_documentation/infinium_assays/infinium-gsa-pgx d=data/p0/gsa_v4_pgx; mkdir -p "$d" for f in idats_Demo_36.zip GSA-PGx-48v4-0_20079540_E2_bpm.zip GSA-PGx-48v4-0_20079540_E2_csv.zip \ GSA-PGx-48v4-0_20079540_E2_ClusterFile.zip SampleSheetTemplate_GSAv4PGx_2beadchips.csv; do get "$SUP/$f" "$d" done # GDA v1 manifest/cluster files (note: the "Demo 36" bundle is a GenomeStudio project, not IDATs) d=data/p0/gda_v1; mkdir -p "$d" get "$GDA/infinium-global-diversity-array-8-v1-0-D1-manifest-file-bpm.zip" "$d" get "$GDA/infinium-global-diversity-array-8-v1-0-D1-manifest-file-csv.zip" "$d" get "$GDA/infinium-global-diversity-array-8-v1-0-D1-cluster-file.zip" "$d" get "https://support.illumina.com/content/dam/illumina-support/documents/downloads/productfiles/global-diversity-array/infinium-global-diversity-array-8-v1-0_D1_SampleSheet_Demo_36.csv" "$d" # Bioconductor IDAT fixtures (Artistic-2.0, redistributable) — fetched as source tarballs, no R needed d=data/p0/bioc; mkdir -p "$d" for pkg in IlluminaDataTestFiles hapmap370k; do url=$(curl -sL "https://bioconductor.org/packages/release/data/experiment/html/$pkg.html" \ | grep -oE "\.\./src/contrib/${pkg}_[0-9.]+\.tar\.gz" | head -1 || true) [[ -n "$url" ]] && get "https://bioconductor.org/packages/release/data/experiment/${url#../}" "$d" \ || echo "!! could not resolve $pkg tarball" done unpack data/p0 ;; p1) d=data/p1/1kg_omni_broad; mkdir -p "$d" for f in HumanOmni2.5-4v1-Multi_B.bpm HumanOmni2.5-4v1_B.csv; do get "$G1K/broad_intensities/$f" "$d" || true; done echo "Listing broad_intensities/ (pick EGT + the 107 GB Omni25_idats_gtcs_2141_samples.tgz):" curl -s "$G1K/broad_intensities/" | grep -o 'href="[^"]*"' | cut -d'"' -f2 | grep -v '^?' || true echo "Then: bash scripts/fetch_data.sh p1-big (downloads the 107 GB archive)" d=data/p1/1kg_omni_sanger; mkdir -p "$d" echo "Sanger set index:"; curl -s "$G1K/sanger_intensities/" | grep -o 'href="[^"]*"' | cut -d'"' -f2 | grep -v '^?' || true d=data/p1/gse165845; mkdir -p "$d" get "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE165nnn/GSE165845/suppl/GSE165845_RAW.tar" "$d" ;; p1-big) get "$G1K/broad_intensities/Omni25_idats_gtcs_2141_samples.tgz" data/p1/1kg_omni_broad ;; p2) d=data/p2; mkdir -p "$d/gse96909" "$d/gda_pgx480" get "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE96nnn/GSE96909/suppl/GSE96909_RAW.tar" "$d/gse96909" get "https://s3.amazonaws.com/webdata.illumina.com/downloads/productfiles/global-diversity-array-pgx/GDAPGx_Demo_idats.zip" "$d/gda_pgx480" ;; p6) # GRCh38 primary assembly (Ensembl release 110; contigs named 1..22, X, Y, MT like the GSA/GDA manifests) d=data/p6; mkdir -p "$d" ENS=https://ftp.ensembl.org/pub/release-110/fasta/homo_sapiens/dna f=Homo_sapiens.GRCh38.dna.primary_assembly.fa.gz [[ -f "$d/$f" ]] || curl -sSfL -o "$d/$f" "$ENS/$f" want=$(curl -sSfL "$ENS/CHECKSUMS" | awk -v f="$f" '$3==f {print $1" "$2}') got=$(sum "$d/$f" | awk '{print $1" "$2}') [[ "$want" == "$got" ]] || { echo "!! checksum mismatch for $f ($got vs $want)"; exit 1; } [[ -f "$d/GRCh38.primary.fa" ]] || gzip -dc "$d/$f" > "$d/GRCh38.primary.fa" echo "FASTA ready: $d/GRCh38.primary.fa (the .fai is built on first use)" ;; *) echo "unknown tier $tier"; exit 2;; esac echo "checksums in $sums"