2 Commits

Include renames

Author	SHA1	Message	Date
kemal	8758178df6	v2 methylation control QC (WIP): simurg methyl qc|convert-manifest (MET-001..018) ... Methylation CSV manifest reader (MET-002/003), raw M/U assembly with bead masking (MET-005), pOOBAH detection p-values, noob background correction, linear/nonlinear dye bias, beta and M-values (MET-010..012), the 21 methylation control metrics (MET-006, bs-conv red-bg set option), per-sample ctrl/cgs tables, summary tsv/xlsx/html with the detection histogram and a beta PCA, pcs.tsv.gz, controls_raw/controls_qc.tsv; methylation datasets load in qc report (MET-014); qc controls --array-type methylation; minfi-style Sentrix_ID/Sentrix_Position sheet keys. Vendor EPIC manifests carry a 5th field on some control lines: >= 4 fields accepted. Runs on the public minfiDataEPIC set (3 x NA12878).	2026-09-29 00:13:22 +01:00
kemal	a4c9c2d7d8	P5a: QC — control metrics, thresholds, status, contamination, relatedness, locus summary ... - qc/controls: canonical control names (QC-002), bkg/offset (QC-003), 13 genotyping metrics (QC-004/005), missing/zero-divisor handling (QC-007/008); controls_raw.tsv / controls_qc.tsv (QC-009/011) incl. compat CSVs - qc/thresholds + profiles: YAML schema, validation codes, precedence, shipped profiles, auto (QC-020..025) - qc/status: functional PASS/FAIL/NA, control CLEAR/FLAGGED, flags (QC-030..033) - qc/contamination: BAF regression; bit-compatible with gtc2vcf BAFregress (36/36, K-017), exact mode too - qc/relatedness: KING-robust, duplicates, Mendelian errors, pedigree from sheet (IN-018) - qc/locus_summary: OUT-072, bit-identical to BeadArrayFiles except ChiTest (K-018) - qc/suggest: suggest-thresholds (QC-026) - pipeline/qc: disk-backed cohort store; CLI qc controls|samples|contamination|relatedness|loci|suggest-thresholds - genotype: control tables (OUT-070), het_rate, QC columns, cohort QC - tests: unit + oracle (BAFregress plugin, BeadArrayFiles locus summary)	2026-09-28 08:35:10 +01:00